Artificial leather is the material which has wide range of use in life from fashion garment, upholstery to technical applications such as defense industries. PVC artificial leather is preferred material by manufacturers because of its low cost and modification can be done easily by using true plasticizers which are fitting for purpose. In this study, number of six different plasticizers which are non-phthalate plasticizers; trioctyl trimelliate (TOTM), tributyl trimelliate (TBTM), dioctyl terephthalate (DOTP), tributyl citrate (TBC), dioctyl adipate (DOA) and dioctyl succinate (Plast BIO) were used for obtaining artificial leather. To characterize the properties of different kinds of plasticizer in artificial leather, mechanical tests including tensile and tear strengths, elongation at break, cold flexibility and effects of migrability tests were applied. Materials were formulated at three degrees of plasticizers ratios. Also, chemical changes during plasticization were observed using FTIR spectroscopy with ATR accessory, according to types and used levels of plasticizers. In conclusion, plasticizers showed different properties, i.e. material with TOTM plasticized had maximum tear and tensile strengths, while DOA and TBC including materials showed maximum elongation under same load. Considering cold flexibility of six plasticizers, DOA, BIO and TBC have more resistance to cold were obtained, respectively. In addition, migration studies showed that plasticizers including TOTM and TBTM have the least migration properties.