Climate change and its effects on the planning of cities require new dynamics for designing new expansion zones or neighborhood development projects. In conceptual phases, decision-makers, architects, planners, and engineers must consider extreme weather events and increased wind speeds in cities due to climate change to ensure the safety of pedestrians. Proposed building layouts, geometrical parameters, and features should be investigated in an artificial environment to satisfy wind behavior for acceptable conditions. Computational Fluid Dynamics (CFD) software provides insight into wind effects on the pedestrian level for the proposed layout of buildings and the surrounding area. This insight can boost the design process without conducting experimental wind tunnel tests. This study aims to assess the impact of building geometry (height, width, length) and building spacings in urban development projects for the safety and comfort of users in pedestrian-level wind environments with CFD simulations. The case area of this study is the first phase of an urban regeneration area in Izmir. The proposed layout is analyzed with prevailing wind speeds and directions to identify the dangerous and comfortable regions around buildings. Sub-configurations of buildings are simulated in CFD software to compare with existing wind tunnel tests for verification and validation. A design proposal with building features is evaluated with validated CFD parameters to examine the impact on pedestrian-level wind speeds. Mean speeds for corresponding comfort and safety limits of categorized human activities are compared to findings to identify suitable locations for these activities around buildings. Design parameters of urban layout; distance between buildings, height, and balconies on facades showed significant effects on pedestrian level wind environment. Building height among these parameters proved to be a decisive feature that should be considered in the early design stages.