Building envelope design is very important for energy efficiency in the building due to control the mass and energy transfer between the internal and external environments. Additionally, this performance is also important for obtaining indoor air quality and comfort conditions in the built environment. The study aims to analyze the heat and moisture performance of the different building exterior wall types composed of the different structural elements and insulation materials. Two different analysis models were used for this study. The objective of the thesis is to predict the physical, chemical and biological problems in the building envelope that will arise due to condensation in the design stage. So, saving cost and time will be provided to consumers. In the scope of the thesis, the heat and moisture performance of 21 different wall sections that composed commonly used structural body elements (concrete, brick and aerated concrete) and insulation materials (XPS, EPS and MW) in different insulation situations (internal insulation, external insulation and non-insulated situation) were analyzed in steady and transient regimes. The interlayers with a risk of condensation were determined in the result of this study. The results of the two different analysis methods were evaluated and the differences of the methods were revealed. As a result of the study, it has been shown that the placement of the insulation material on the exterior side is more suitable for moisture.