Since the emergence of the SARS-CoV-2 virus, which causes the COVID-19 disease, it continues despite the application of many vaccines and drug treatments. It has continuously mutated, therefore the effect of vaccines and drug treatments has begun to decrease and a permanent solution has not been found. The main hypothesis of thesis is that the conserved regions in the SARS-CoV-2 genome can be potential targets for new vaccines and drugs to eradicate the Covid-19 pandemic. In this study, a total of 807 sequences of the first emerging clades (L, O, S) of the SARS-CoV-2 human virus and its variants in the category of Variants of Concern (Alpha, Beta, Gamma, and Delta) were taken from different dates, and population genetic statistical tests were conducted. Human specific SARS-CoV-2 sequence analyses showed that the evolution of all viral proteins are primarily driven by negative selection. Interspecies tests using the RaTG13 Bat coronavirus, which has the most similar genome to the SARS-CoV-2 virus genome, showed that there was no fixed amino acid change divergence between the bat and human virus sequences for Membrane, Nsp8, Nsp10, and Nsp16, indicating high conservation. Then, a list of the amino acid changes among the SARS-CoV-2 human clades and variants was prepared for Membrane, Nsp8, Nsp10, and Nsp16. Since the regions outside of these changes are the most conserved, the functions of the Membrane, Nsp8, Nsp10, and Nsp16 and and interactions with other viral proteins should be investigated as potential targets for new vaccines and drug treatments.