Development of fluorescent carbon-dots for biological imaging
Kavuranpala, Tuğçe, author.

Development of fluorescent carbon-dots for biological imaging

Kavuranpala, Tuğçe, author.

Yazar Ek Girişi
Kavuranpala, Tuğçe, author.

Fiziksel Tanımlama
xvi, 131 leaves: charts;+ 1 computer laser optical disc.

Carbon dots are called carbon quantum dots or carbon nanoparticles (NPCs), and their use has recently started to increase thanks to their good biocompatibility, unique optical properties, easy synthesis, and low toxicity. Different kinds of carbon sources and amine sources also used as different dopes of chemical create a different emission color of CDs under UV-lamp. In this study, our aim to provide a simple synthesis of carbon dots with high quantum efficiency and low toxicity for use in cell imaging. Nitrogen and sulfur-doped carbon dots were synthesized using citric acid and thiourea, and emission was obtained in the blue-green region. After the synthesized carbon dots were seeded to the A549 cell culture, intracellular viability and cell toxicity results showed that carbon dots did not affect cell viability at certain concentrations. Afterward, the carbon dots are combined with gold nanoparticles and it is aimed to attach the gold to the surface of the carbon dots. Our aim here is to increase the efficiency of carbon dots, which give an emission peak at 550 nm, thanks to gold nanoparticles. As a result of these studies, it was proved by DAPI staining that the carbon dot is directed to the nucleus of the cell. Since it does not create a toxic effect and is transported to the cell nucleus, it allows it to be used in intracellular drug transport and imaging processes in the next stages.

Konu Başlığı
Imaging systems in biology
Quantum dots.

Yazar Ek Girişi
Özçelik, Serdar,

Tüzel Kişi Ek Girişi
İzmir Institute of Technology. Chemistry.

Tek Biçim Eser Adı
Thesis (Master)--İzmir Institute of Technology:Chemistry.
İzmir Institute of Technology: Chemistry --Thesis (Master)

Elektronik Erişim
Access to Electronic Versiyon.

KütüphaneMateryal TürüDemirbaş NumarasıYer NumarasıDurumu/İade Tarihi
IYTETezT002415QD181.C1 K21 2021Tez Koleksiyonu