Thermal performance of different glazing systems have been investigated with a comprehensive parametric study numerically. In order to analyze the heat transfer through the windows, CFD simulations have been performed considering many affecting parameters. The aim of the study is to determine the appropriate window configurations according to the different cities that have different climatic conditions of Turkey which are: Ağrı, Sivas, Amasya and İskenderun. For this purpose, the glazing part of the window has been analyzed because of having low thermal resistance due to the gap widths, temperature differences and the emissivity values. Four physical models of glazing systems were designed. The thickness of glazing units is 4 mm and the height is 1 m as a constant. For investigating the effect of the cavity dimension on the heat transfer, two gap widths usually used, are determined and combined in different ways which as 12–12 mm, 16–16 mm, 12–16 mm and 16–12 mm. Different boundary conditions are defined according to ambient temperature of inside and outside. Radiation heat transfer is included in the calculations and various low-e coatings are defined to analyze the radiation effect on the heat transfer coefficient. As a result of this study, temperature and velocity profiles are different in all scenarios. The effect of gap width on the U-value is more distinguished in the low temperature difference. Heat loss can be minimized significantly with using low-e material and the emissivity value is more effective on the wider gap widths. It is also shown that the optimum air layer thickness of the triple pane window differ from the temperature difference significantly. The highest U-values were obtained in 12-12 mm gap width glass. It was determined that the heat losses can be reduced by using 16-12 mm gap width glass about 2% and 8% in cold regions and in warm regions respectively.