This study investigates the thermal performance and indoor environment conditions of naturally and hybrid ventilated industrial buildings. Numerical analyses and experimental measurements were conducted in a tobacco warehouse in İzmir, Turkey. Parametric analyses were performed with three different approaches: i) 15 architectural design strategies are evaluated by using a sensitivity analysis. It is found that roof insulation thickness, shading projection factor, and shading angle have significant impact on heating and cooling requirements. In addition, the most influential factors on operational CO2 emissions are thickness of insulation material and conductivity of thermal insulation material. ii) Vertical and volumetric temperature gradients, crucial for stored product quality, are assessed through field measurements and CFD simulations. Ceiling-mounted radiant cooling systems reduced indoor temperatures by 3°C, while floor heating systems increased temperatures by 7°C, ensuring a consistent range of 21- 25°C by providing a range at defined indoor temperature values. Maximum loads are determined as 12.9W/m2 for cooling and 39.6W/m2 for heating. iii) The air change effectivenesses of different ventilation conditions are analysed. Four additional fans improved air exchange quality and decreased the volumetric mean age of air (AoA) from 1230 to 525 seconds. It is indicated that, while additional fans may decrease the mean AoA, maximizing the fan operation capacities is not obligatory to achieve increased air change effectiveness. Besides, the analysis of various fan operation scenarios significantly improves indoor environment conditions and energy efficiency. This thesis emphasizes the importance of design parameters in influencing indoor environmental conditions and energy consumption. The investigation of thermal air mixing and conditioning strategies underscores the need for a combined experimental and numerical approach. The findings contribute to effective solutions for warehouses storing temperature-sensitive products, ensuring optimal storage conditions and mitigating temperature variations during logistics operations.