Macular Degeneration is a common, progressive, multifactorial, and complex eye disorder among people over 50 years old. The etiology of Macular Degeneration is still not known. The main hypothesis of thesis is that chronic inflammation and oxidative stress are the major factors for the development of AMD. Firstly, the current Literature are reviewed to understand genetic, and nongenetic risk factors of AMD development, transcriptomic of Retina, and molecules that changing with aging. Age, smoking history, gender, race, cardiovascular disease, hypertension, diabetes, hyperlipidemia, kidney disease, and HIV infection status were chosen as non-genetic factors. Genetic factors included ARMS2, C2, C3, CFH, CFI, CX3CR1, IL10RA, IL28B, LIPC, and SYN3. Secondly, the influence of these factors on early AMD development was investigated by focusing on patients with chronic HIV infection. Based on the idea that patients with acquired immunodeficiency syndrome (AIDS) can be a good model for Aging. Older age was observed the primary risk factor for AMD development. Smoking, cardiovascular disease, hypertension, diabetes and injection drug use, CFH(RS800292), IL10RA(RS3135932) and IL10RA(RS2229113) were also observed to be significantly associated with AMD. According to pathway enrichment analyses, complement activation pathways, lipid metabolism pathways, cholesterol transport, receptor-mediated endocytosis, and extracellular matrix organization mechanism can be involved in AMD development. Multivariable models accounting for other variables identified IL10RA (RS3135932) and injection drug as risk factors for AMD. For the first time, a significant association between IL10RA(RS3135932) and AMD is observed. As a conclusion, chronic inflammation and oxidative stress can be mainly risk factor for AMD development.