In this study, acidic mesoporous catalysts, sulfonated and non-sulfonated Zr-SBA15 (08), Zr-SBA15 (10), Ti-SBA15 (10) and Ti-SBA15 (20), were prepared for oxirane ring opening reaction of epoxidized soybean oil with methanol. Two different amounts of Zr and Ti incorporated into SBA-15. They were prepared by hydrothermal synthesis. Their sulfated forms were prepared by treating Zr-SBA15 based catalyst with H2SO4 and Ti-SBA15 based catalysts by (NH4)2SO4. The catalytic activities of all catalysts in oxirane ring opening reaction were tested in a 250 ml glass batch reactor at 60 oC. The catalysts characterisation showed that Zr was succesfully loaded into SBA-15 catalyts. Low Ti content (Ti-SBA-15(20) incorporated into SBA-15 whereas anatase was observed for high Ti content (Ti-SBA15 (20)). All the catalysts had mesopore structure and were acidic. While acidity increased with sulfation significantly, slight acidity change was observed with incoporated metal amount. Zr-SBA15 based catalysts had higher acidity than Ti-SBA15 based catalysts. The catalysts showed different activities in oxirane ring opening reaction. The activities of the catalysts affected from their acidity. Zr based catalysts showed higher catalytic activity than Ti based catalysts. Higher activities were observed over non sulfated catalysts even they had low acidity. Activity of the catalysts decreased with the acidity. The formation of soy based polyols were determined by FTIR and H-NMR analysis. The highest epoxide conversion was observed over Zr-SBA15 (08) which was 84.08%. This activity was followed by Zr-SBA15 (10) which provided 57.77 %.