Modeling masonry structures has always been a difficult subject due to the lack of information about the behavior, the heterogeneity of the masonry materials and complex geometries of masonry structures. In terms of the computational costs and complexity, several methods are proposed in the literature. In this thesis, the capabilities of the meso-scale modeling technique are investigated by means of two experiments selected from the literature and the seismic response of an ancient lighthouse. Brick and mortar type structure is idealized as expanded units surrounded by zero thickness cohesive interfaces representing the mortar behavior. This means that the failure of mortar layers is considered explicitly by means of cohesive surfaces whereas the mechanical response of expanded units is described by Drucker-Prager/Cap model. This approach is used to simulate the in-plane and the outof-plane behavior of masonry walls reported in the literature. After validating the models with the experimental results, implicit-dynamic time history analyses of an ancient lighthouse are conducted by using 2 different earthquake records. The influence of mortar properties on the energy dissipation mechanisms and collapse pattern of the structure are investigated by means of a parametric study. As an attempt to identify the critical earthquake level corresponding to the initiation of sliding within the lighthouse, a set of additional analyses are conducted with scaled earthquake records.