Asymmetric synthesis of 5,6-dihydro-2H- pyran-2-one derivatives
Akçok, İsmail, author.

Asymmetric synthesis of 5,6-dihydro-2H- pyran-2-one derivatives

Akçok, İsmail, author.

Yazar Ek Girişi
Akçok, İsmail, author.

Fiziksel Tanımlama
xvii, 122 leaves:+ 1 computer laser optical disc.

α,β-unsaturated lactone derivatives are very important structural core which are isolated from nature and shown as source for several biological activities. Biologically active styryl δ-lactones are well known α,β-unsaturated-δ-lactones. Up to date, many α,β- unsaturated-δ-lactones and their analogues have been isolated and synthesized, exhibiting promising anti-proliferative properties against different cancer cell lines. In this thesis, large scale asymmetric syntheses of (R)-4’-methylklavuzon and (R)- 2’-methylklavuzon were completed successfully. Also, syntheses of heteroatom functionalized naphthyl substituted novel α,β-unsaturated-δ-lactone (5,6-dihydro-2Hpyran- 2-one) derivatives, α,β-unsaturated-γ-lactone (furan-2(5H)-one) derivatives and 7- membered α,β-unsaturated lactone (6,7-dihydro-5H-oxepin-2-one) derivatives were accomplished. Development of a method for one-pot synthesis of 6-membered α,β-unsaturated- δ-lactone was also studied, and a new vinylogous aldol addition method was developed. By this method, new α,β-unsaturated methyl esters were prepared via dienolate formation starting with methyl buten-3-oate.

Konu Başlığı

Yazar Ek Girişi
Çağır, Ali

Tüzel Kişi Ek Girişi
İzmir Institute of Technology. Chemistry.

Tek Biçim Eser Adı
Thesis (Doctoral)--İzmir Institute of Technology: Chemistry.
İzmir Institute of Technology: Chemistry--Thesis (Doctoral).

Elektronik Erişim
Access to Electronic Versiyon.

LibraryMateryal TürüDemirbaş NumarasıYer NumarasıDurumu/İade Tarihi
IYTE LibraryTezT001326QD305.A2 A31 2014Tez Koleksiyonu