Aspirin is the most preferred pain reliever among the people. Salicylic acid (SA) is the drug active ingredient of aspirin and has an antipyretic, analgesic, and antiinflammatory properties. It is also used in the treatment of acne, fungus, varicose veins, and calluses. The aim of this project is to prepare Fe and Fe-Ni based molecularly imprinted polymers (MIPs) for solid phase extraction of salicylic acid and then determine it with HPLC-DAD. MIPs were prepared by using methanol as porogen, 4- vinyl pyridine as monomer, ethylene glycol dimethacrylate cross linker and the analyte, salicylic acid, as the template. Fe and Fe-Ni is used to prevent the hydroxyl and carboxyl groups in the structure of salicylic acid from forming hydrogen bonds between themselves. In this study, a magnetic molecular imprinting solid phase extraction (MMISPE) methodology was proposed for determination of salicylic acid to HPLC-DAD analysis. For this goal, critical experimental parameters of MMISPE method were optimized and determined as follows; sorbent amount of 25.0 mg for 10.0 mL of 5.0 mgL-1 working solution, sorption time of 30 min and MeOH: Acetic acid (9:1) as desorption solvent. The proposed method was repeated with same sorbent and MIPs show quantitative sorption in three times. For characterization of MIPs and NIPs, EDX and XRD analysis was done. In XRD diffractogram, the peaks are relatively low intensities indicate that the material is mostly amorphous. Also, Fe and Ni peak cannot observe because of the trace amount of Fe and Ni in the polymer in the EDX graph.