Dual therapy opportunities for tuberculosis and prostate cancer based on crystal engineering principles
tarafından
 
Arpacıoğlu, Merve, author.

Başlık
Dual therapy opportunities for tuberculosis and prostate cancer based on crystal engineering principles

Yazar
Arpacıoğlu, Merve, author.

Yazar Ek Girişi
Arpacıoğlu, Merve, author.

Fiziksel Tanımlama
xi, 52 leaves: charts;+ 1 computer laser optical disc.

Özet
Within this work, it is aimed to facilitate dual therapy opportunities for the treatment of tuberculosis and prostate cancer separately based on crystal engineering principles. In this regard, a quinolone family member antibiotic namely Sparfloxacin (SPX) is combined with another antibiotic called 4-aminosalicylic acid (4-ASA). Due to the drug-drug combination, it is expected to have superior biological activity since both drugs are stated and offered to be used in the treatment of tuberculosis. In addition to that, Apalutamide (APA) a recent drug in the treatment of castration-sensitive metastatic prostate cancer (CSMPC), is metallo-encapsulated by using zeolitic imidazolate framework-8 (ZIF-8). Owing to pH-sensitive decomposition, the new formulation is expected to combine the benefit of free zinc release and APA release to the targeted cancerous section. Both new compounds are synthesized characterized by various methods such as single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), Fourier-transform infrared radiation (FTIR), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and high-performance liquid chromatography (HPLC).

Konu Başlığı
Pharmaceutical biotechnology.
 
Biotechnology.

Yazar Ek Girişi
Şanlı Mohamed, Gülşah,

Tüzel Kişi Ek Girişi
İzmir Institute of Technology. Biotechnology.

Tek Biçim Eser Adı
Thesis (Master)--İzmir Institute of Technology: Biotechnology.
 
İzmir Institute of Technology: Biotechnology--Thesis (Master).

Elektronik Erişim
Access to Electronic Versiyon.


LibraryMateryal TürüDemirbaş NumarasıYer NumarasıDurumu/İade Tarihi
IYTE LibraryTezT002114TP248.2 .A77 2019Tez Koleksiyonu