Refletions -- How to Chase a Red Herring and Come up with a Smallmouth Bass -- Interferon Research BC (Before Cloning) -- Purification and Cloning of Interferon Alpha -- Interferons and Their Signaling Pathways -- Type I Interferon: The Ever Unfolding Story -- The Receptor of the Type I Interferon Family -- IFN-?: Recent Advances in Understanding Regulation of Expression, Biological Functions, and Clinical Applications -- Cell Type-Specific Signaling in Response to Interferon-? -- Interferon Research: Impact on Understanding Transcriptional Control -- Recognition of Pathogens, Molecular Mechanism of Interferon Beta Induction -- TLR-Mediated Activation of Type I IFN During Antiviral Immune Responses: Fighting the Battle to Win the War -- Regulation of Antiviral Innate Immune Responses by RIG-I Family of RNA Helicases -- Beyond Double-Stranded RNA-Type I IFN Induction by 3pRNA and Other Viral Nucleic Acids -- Interferon-Induced Genes -- The Interferon-Stimulated Genes: Targets of Direct Signaling by Interferons, Double-Stranded RNA, and Viruses -- Structure and Function of the Protein Kinase R -- Virus Defense -- Viral Regulation and Evasion of the Host Response -- Pathogenic Viruses: Smart Manipulators of the Interferon System -- Role of Interferon in Viral Infection and Autoimmunity -- Type I Interferon During Viral Infections: Multiple Triggers for a Multifunctional Mediator -- Type I Interferon in Systemic Lupus Erythematosus.