Design of micelle embedded chitosan nanocomposites for targeted delivery of hydrophobic drugs için kapak resmi
Design of micelle embedded chitosan nanocomposites for targeted delivery of hydrophobic drugs
Cihan, Esra, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
xi, 83 leaves: illustrarions, charts;+ 1 computer laser optical disc.
When successed to synthesize in a nanoparticulate form, chitosan has found to be a very effective biomaterial for drug delivery purposes owing to its extremely attractive characteristics such as its positive charge and pH sensitivity in aqueous medium. However, its structure as it is, is not suitable for oil soluble drugs. Even a close control on the size and shape of chitosan particles alone becomes a state of art and the production of chitosan nanoparticles is very difficult. Therefore, in this study, several methods were designed and used for synthesis of chitosan nanoparticles (<100 nm) with a hydrophobic core that are suitable for oil soluble drugs. Characterization of these nanoparticles were done by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscope (SEM), Scanning Transmission Microscope (STEM), Transmission Electron Microscope (TEM), surface tension and zeta potential measurements. It was concluded that the best method was the coupling of drug loading with simple ionic gelation method among all the others. Hydrophobic drug loaded micelle embedded chitosan nano particles were able to manufactured successfully. The sizes of chitosan particles that embed Pluronic-123 micelles were larger (<100 nm) than the sizes of Pluronic-123 micelles (20 nm) alone. It was also possible to obtain smaller chitosan nanoparticles (<50 nm) that embed drug loaded Pluronic-123 micelles when their structure is modified by Sodiumdodecylsulfate.
Yazar Ek Girişi:
Tek Biçim Eser Adı:
Thesis (Master)--İzmir Institute of Technology: Chemistry.

İzmir Institute of Technology: Chemistry--Thesis (Master).
Elektronik Erişim:
Access to Electronic Versiyon.


Materyal Türü
Demirbaş Numarası
Yer Numarası
Durumu/İade Tarihi
Tez T001550 TP248.65.C55 C57 2016

On Order