Antiproliferative and anticancerogenic effects of 5-ASA and its novel synthesized oligomer için kapak resmi
Antiproliferative and anticancerogenic effects of 5-ASA and its novel synthesized oligomer
Atahanova, Hurshida, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
xi, 58 leaves: illustrarions, charts;+ 1 computer laser optical disc.
In the world, colorectal cancer (CRC) is third common malignant diseases and fourth leading cause of cancer-related death. More recently, epidemiological studies have suggested that regular intake of 5-aminosalicylic acid (5-ASA), the drug used in treatment of inflammatory bowel disease (IBD), reduces the risk of CRC developing in patients with ulcerative colitis. Several action mechanisms of 5-ASA are proposed which are independent from its weak cyclooxygenase (COX) inhibitory property, found overexpressed in many cancer types. Lately, polymeric prodrugs developed which contain bioactive unit and have prolonged activity by sustained release, consequently reduced toxicity. However, large molecular weight and long chain can be challenging in penetrating into the cell membrane. Thus, oligomers with shorter chain of monomer units and lower molecular weight can be preferred choice. In the present study we evaluated antiprolifertaive and anticancerogenic effect of novel synthesized 5-ASA based oligomer compared to its active monomer, 5-ASA in Caco-2, DLD-1, HeLa and CCD-18Co cells. According to MTT, apoptotic rate, cell cycle phase distribution and scratch assay analysis the oligomer showed higher activity compared to its monomer, 5- ASA at lower doses. The oligomer induced cell death and cell cycle arrest in colorectal cancer cells and in HeLa cells. However, no significant induced cell death and cell cycle arrest observed in normal human colon cells, CCD-18Co when exposed to 5-ASA and the oligomer. Overall results indicate that the oligomer can be promising candidate for prodrugs in treatment and prevention of colorectal cancer.
Konu Başlığı:
Yazar Ek Girişi:
Tek Biçim Eser Adı:
Thesis (Master)--İzmir Institute of Technology: Chemistry.

İzmir Institute of Technology: Chemistry--Thesis (Master).
Elektronik Erişim:
Access to Electronic Versiyon.


Materyal Türü
Demirbaş Numarası
Yer Numarası
Durumu/İade Tarihi
Tez T001612 QD382.O43 A86 2017

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