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Development of chitosan based biofoams için kapak resmi
Development of chitosan based biofoams
Development of chitosan based biofoams
Olcay Kurt, Aybike Nil, author.
Fiziksel Tanımlama:
xvi, 177 leaves: charts;+ 1 computer laser optical disc.
Chitosan is a preferred bio-foam material used in many research fields such as tissue engineering and drug delivery due to its unique structural features (wide pH stability, nontoxic-biocompatible-biodegradable, anti-inflammatory, antimicrobial). However, chitosan foams are mechanically too weak to maintain the desired shape until newly formed tissue natures. A wound infection and serious tissue necrosis, endanger human's lives. So, a dressing is required to protect loss of fluids and proteins from the wound area and prevents any bacterial invasion replacing the function of skin temporarily. Therefore controlled drug release from a wound dressing is necessary with a biocompatibility and enough mechanical strength. The aim of this study was the synthesis of mechanically durable - dual porosity chitosan bio-foams to provide a controlled drug release. For this purpose, oil droplets formed in a chitosan solution were used as templates to produce micropores that also contain vancomycin (a model antibiotic-hydrophylic) and curcumin (a model anti-inflammatory-hydrophobic) in the walls of the chitosan matrix with large structural voids. An anionic surfactant, sodium dodecyl sulfate (SDS) alone, was used as a crosslinking agent which was a new approach. Then the structures were characterized by SEM, FTIR, mechanical tests and BET analysis. The chitosan foams have dual pore structures. 1) The intrinsic micro pores that the walls of chitosan matrix have with different morphology that depends on the oil phase. 2) The structural voids that the chitosan matrix have, present even in the absence of an oil phase that depends on the experimental conditions. The mechanical strength of the foams were found to be much higher (up to 250 kPa) compare to the foams produced in literature and suggested to be suitable to use for wound dressing applications. The drug release mechanism of foams were found to depend on the conditions used for foam development and the released kinetics were presented with a mathematical model.
Yazar Ek Girişi:
Tek Biçim Eser Adı:
Thesis (Doctoral)--İzmir Institute of Technology: Chemical Engineering.

İzmir Institute of Technology: Chemical Engineering--Thesis (Doctoral).
Elektronik Erişim:
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