Docking studies on selected sapogenins targeting androgen and estrogen receptors için kapak resmi
Docking studies on selected sapogenins targeting androgen and estrogen receptors
Çömlekçi, Yiğit Ege, author.
Fiziksel Tanımlama:
ix, 105 leaves: charts;+ 1 computer laser optical disc.
Natural products have been used in the treatment of various diseases in history, and they are still in use today. Sapogenins are natural products derived from plant and animal sources that also have numerous biological activities. Furthermore, some sapogenins have been found to be active in common cancers such as prostate and estrogen alpha-mediated breast cancer and exert their effects via the androgen and estrogen receptors. For this reason, identifying alternative ligands for these receptors may aid in enhancing the benefits or avoiding adverse effects. Traditional or advanced molecular screening techniques are available with their respective applications. However, these applications have some limitations, such as being complicated and costly or requiring a significant amount of time due to the large number of molecules involved. With advancements in technology, in-silico methods such as molecular docking have developed into a highly accurate and cost-effective method for high throughput screening. Additionally, rapid and high-quality in-silico visualization of docked ligands and their interactions serves as a preliminary step toward determining structure-activity relationships. The molecular docking method was used in this study to identify novel androgen and estrogen receptor ligands, and to evaluate the structure-activity relationship of sapogenin molecules, which were selected from our research group's molecule library. Moreover, the Swiss Target Prediction web service was used to determine the probability of bindings prior to molecular docking. The molecular docking results demonstrated that nine of the selected sapogenins were more bindable to the androgen receptor than testosterone, whereas another nine were found to be more bindable to the estrogen receptor than estradiol. Additionally, immunoblotting was utilized to validate the activity of several molecules by examining their effects on PSA levels for androgen receptor binding.
Yazar Ek Girişi:
Tek Biçim Eser Adı:
Thesis (Master)--İzmir Institute of Technology:Bioengineering.

İzmir Institute of Technology: Bioengineering --Thesis (Master).
Elektronik Erişim:
Access to Electronic Versiyon.


Materyal Türü
Demirbaş Numarası
Yer Numarası
Durumu/İade Tarihi
Tez T002299 QP572.E85 C733 2021

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