Persistent Organic Pollutants (POPs) pose significant human health risks due to their global ubiquity, resistance to environmental degradation, long-range transport, and tendency to accumulate in the environment and food chain because of their affinity for organic matter. They partition between gas and particulate, soil and air, and sediment and water, leading to their presence in agricultural products, meat, and marine and freshwater products. This results in exposure through ingestion, inhalation, and dermal contact. Consequently, a comprehensive screening study was designed to investigate as many groups of POPs as possible. Samples of food, indoor and outdoor air, and settled dust were collected from randomly selected homes and schools in Izmir. Additionally, indoor settled dust samples were collected from cafes, bars, and restaurants. Samples were analyzed using GC/MS for target congeners of PAHs, PCBs, PBDEs, NBFRs, and OPFRs. The measured concentrations and collected survey data were used as input variables for USEPA exposure-risk models to simulate ingestion and inhalation exposures (chronic daily intake), as well as associated health risks using the Monte Carlo simulation. Sampling locations were strategically distributed among rural, suburban, urban areas, and areas downwind of an industrial site to assess the impact of urbanization. Within the scope of this thesis work, the most comprehensive dataset has been generated among studies that have entered the global literature, providing information on the levels of such a high number of target POPs analyzed in environmental and food samples.