
Development of hydrogels via photocrosslinking of wool proteins
Başlık:
Development of hydrogels via photocrosslinking of wool proteins
Yazar:
Yakar, İrem, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
x, 67 leaves: charts;+ 1 computer laser optical disc.
Özet:
Hydrogels, with high water absorption capacity and tissue-like properties, create a moist environment ideal for wound healing. This study focuses on synthesizing bioactive gallic acid (GA) and carbon dots (CDs) containing hybrid hydrogels based on oxidized keratin (KTS), a natural protein, and Pluronic F127, a synthetic polymer for wound healing applications. Methacrylated forms of the KTS and F127 (KTSMA and F127MA) were synthesized using methacrylic anhydride, and the functionalized forms were confirmed using spectroscopic methods. KTSMA and F127MA were cross-linked under UV light using an Irgacure 2959 photoinitiator to form self-standing hydrogels. Three hydrogels were prepared: K4 (4% KTSMA), K7.5 (7.5% KTSMA), and KP7.5 (4% KTSMA + 3.5% F127MA), and their viscoelastic, swelling, degradation and morphological properties were determined. Cell proliferation tests showed that all the hydrogels supported cell growth. KP7.5 hydrogels exhibited robust mechanical and degradation properties. Carbon dots were synthesized using curcumin and l-lysine and shown to have modest antibacterial properties against S. aureus. Their structural and optical properties were characterized. Multifunctional hydrogels, KPGA, KPCD, and KPGACD, were obtained by incorporating GA and the CDs into the KP7.5 hydrogel. GA-containing hydrogels exhibited notable antioxidant activity, as assessed by the DPPH test. Considering their biocompatibility, these hydrogels have potential use in wound healing applications.
Yazar Ek Girişi:
Tüzel Kişi Ek Girişi:
Tek Biçim Eser Adı:
Thesis (Master)--İzmir Institute of Technology:Chemical Engineering.
İzmir Institute of Technology: Chemical Engineering --Thesis (Master).
Elektronik Erişim:
Access to Electronic Versiyon.