Biological NMR Spectroscopy. için kapak resmi
Biological NMR Spectroscopy.
Başlık:
Biological NMR Spectroscopy.
Yazar:
Markley, John L.
ISBN:
9780195357424
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 online resource (375 pages)
İçerik:
Table of Contents -- Introduction -- Acknowledgments -- Foreword -- The Founders Medal -- Section 1: History of Biological NMR Spectroscopy -- Chapter 1: Simple Insights from the Beginnings of Magnetic Resonance in Molecular Biology -- Chapter 2: Choice of Problems in the Early Days of Biological NMR Spectroscopy -- Chapter 3: Early Days of Biochemical NMR -- Chapter 4: William D. Phillips Memorial Lecture -- Section 2: Protein Structural Studies -- Chapter 5: Flexibility and Function of the Escherichia coli trp Repressor -- Chapter 6: Heteronuclear Strategies for the Assignment of Larger protein/DNA complexes: Application to the 37 kDa trp Represser-Operator Complex -- Chapter 7: Design of Novel Hemoglobins -- Chapter 8: The Role of NMR Spectroscopy in Understanding How Proteins Fold -- Chapter 9: NMR Approaches To Understanding Protein Specificity -- Chapter 10: NMR and Mutagenesis Investigations of a Model Cis:Trans Peptide Isomerization Reaction: Xaa[sup(116)]-Pro[sup(117)] of Staphylococcal Nuclease and its Role in Protein Stability and Folding -- Chapter 11: A Solid-State NMR Approach to Structure Determination of Membrane Associated Peptides and Proteins -- Chapter 12: NMR Approaches to the Heat-, Cold-, and Pressure Induced Unfolding of Proteins -- Chapter 13: Multidimensional NMR Investigation of the Neurotoxic Peptide Mastoparan in the Absence and Presence of Calmodulin -- Chapter 14: NMR of Larger Proteins: An Approach to the Structural Analyses of Antibody -- Chapter 15: Selective Chemical Deuteration of Aromatic Amino Acids: A Retrospective -- Chapter 16: The Interaction of Antigens and Superantigens with the Human Class II Major Histocompatibility Complex Molecule HLA-DR1 -- Chapter 17: Chorismate Mutase, Essentially a Template Enzyme -- Section 3: Nucleic Acids.

Chapter 18: Computing the Structure of Large Complexes: Modeling the 16S Ribosomal RNA -- Chapter 19: Design and Characterization of New Sequence Specific DNA Ligands -- Chapter 20: Determination by [sup(1)]H NMR of a Slow Conformational Transition and Hydration Change in the Consensus TATAAT Pribnow Box -- Section 4: In vivo Spectroscopy -- Chapter 21: Clinicians Need Localized Proton MRS of the Brain in the Management of HIV-Related Encephalopathies -- Chapter 22: Nuclear Magnetic Resonance Spectroscopy Studies of Cancer Cell Metabolism -- Chapter 23: Ex Vivo Multinuclear NMR Spectroscopy of Perfused, Respiring Rat Brain Slices: Model Studies of Hypoxia, Ischemia, and Excitotoxicity" -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- W -- X.
Özet:
This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.
Notlar:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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