Cover -- Half-title -- Title -- Copyright -- Dedication -- Contents -- Foreword 1 -- Foreword 2 -- Preface -- Acknowledgements -- Acknowledgements -- Chapter 1 Introduction -- Chapter 2 Methods -- Chapter 3 Results: cocaine -- Introduction -- Infections -- Bacterial infections -- Mycoses -- Parasitic infections -- Viral infections -- Comments -- Neoplastic disease -- Comments -- Musculoskeletal system disease -- Digestive system disease -- Comments -- Stomatognathic disease -- Respiratory system disease -- Comments -- Otorhinolaryngological disease -- Comments -- Nervous system disease -- Cerebrovascular studies -- Comments -- Stroke and subarachnoid hemorrhage -- Comments -- Autonomic nervous system diseases -- Comments -- Central nervous system disease -- Comments -- Demyelinating disorders -- Comments -- Neurological manifestations -- Comments -- Sleep disorders -- Comments -- Ocular disease -- Comments -- Male urological disease -- Male genitalia -- Renal dysfunction -- Miscellaneous renal dysfunction -- Comments -- Sexual dysfunction -- Genital ulcer disease -- Immunology -- Hypertension and renal disease -- Rhabdomyolysis -- Acute renal failure -- End-stage renal disease -- Summary -- Female genital and neonatal/congenital disease -- Genital ulcer disease -- Pelvic inflammatory disease -- Pregnancy complications and cocaine -- Miscellaneous pregnancy and infant studies -- Pre-eclampsia and cocaine -- Umbilical artery velocimetry -- Cardiovascular studies in fetuses and infants exposed to cocaine -- Other congenital studies in fetuses and infants exposed to cocaine -- Congenital syphilis -- Subependymal cysts -- Urogenital defects -- Comments -- Female genital disorders -- Pregnancy complications and cocaine -- Pre-eclampsia -- Cardiovascular studies -- Congenital syphilis -- Other congenital conditions -- Cardiovascular disease.

Coronary artery reactivity -- Chest pain, ischemia, electrocardiology changes, and acute myocardial infarction -- Cardiac morphological changes -- Coagulation studies and aortic disease -- Comments -- Coronary artery status -- Chest pain, injury, electrocardiology changes, and acute myocardial infarction -- Cardiac morphology -- Coagulation defects and aortic disease -- Dermatological disease -- Comments -- Nutritional and metabolic disease -- Nutritional studies -- Comments -- Metabolic disorders and cocaine use -- Comments -- Hyperthermia, rhabdomyolysis, excited delirium, and cocaine toxicity -- Comments -- Endocrine system disease -- Comments -- Immune system disease -- Comments -- Environmental disease -- Trauma -- Trauma related to speci c causes -- Related trauma studies -- Comments -- Body stuffers and packers -- Comments -- Other pathological conditions -- Comments -- Infections -- Overall association: supported by some evidence -- Clinical implications -- Neoplastic disease -- Overall association: supported by some evidence -- Musculoskeletal system disease -- Digestive system disease -- Overall association: supported by strong evidence -- Clinical implications -- Stomatognathic disease -- Respiratory system disease -- Asthma -- Overall association: supported by strong evidence -- Respiratory changes -- Overall association: supported by strong evidence -- Otorhinolaryngological disease -- Sensory changes -- Overall association: supported by strong evidence -- Oral lesions -- Overall association: supported by some evidence -- Nasal signs and symptoms -- Overall association: supported by strong evidence -- Midline nasal lesions -- Overall association: supported by strong evidence -- Clinical implications -- Thermal injury -- Overall association: supported by some evidence -- Nervous system disease -- Cerebrovascular disease.

Overall association: supported by some evidence -- Strokes and subarachnoid hemorrhage -- Overall association: supported by strong evidence -- Clinical implications -- Autonomic nervous system dysfunction -- Overall association: supported by strong evidence -- Central nervous system atrophy -- Overall association: supported by some evidence -- Central nervous system: seizures -- Overall association: supported by strong evidence -- Central nervous system: crack dancing -- Overall association: supported by some evidence -- Demyelinating studies: white and gray matter changes -- Overall association: supported by some evidence -- Neurological manifestations -- Overall association: supported by some evidence -- Sleep -- Overall association: supported by some evidence -- Ocular disease -- Corneal changes -- Overall association: supported by some evidence -- Retinal damage -- Overall association: supported by some evidence -- Iritis -- Overall association: supported by some evidence -- Color vision changes -- Overall association: supported by some evidence -- Acute-angle-closure glaucoma -- Overall association: supported by some evidence -- Male urological disease -- Genital ulcer disease -- Overall association: supported by some evidence -- Sexual dysfunction -- Overall association: supported by some evidence -- Renal dysfunction -- Overall association: supported by strong evidence -- Clinical implications -- Female genital and neonatal/congenital disease -- Female genital disorders -- Overall association: supported by some evidence -- Pregnancy complications -- Overall association: supported by some evidence -- Cardiovascular infant studies -- Overall association: supported by strong evidence -- Congenital syphilis -- Overall association: supported by some evidence -- Congenital anomalies -- Overall association: supported by some evidence.

Cardiovascular disease -- Coronary artery disease -- Overall association: supported by strong evidence -- Chest pain, ischemia, electrocardiography changes, and acute myocardial infarct -- Overall association: supported by strong evidence -- Cardiac morphology changes -- Overall association: supported by some evidence -- Coagulation studies -- Overall association: supported by strong evidence -- Dermatological disease -- Overall association: supported by some evidence -- Nutritional and metabolic disease -- Nutrition -- Overall association: supported by some evidence -- Metabolic disorders -- Overall association: supported by some evidence -- Hyperthermia, rhabdomyolysis, excited delirium, and cocaine toxicity -- Overall association: supported by strong evidence -- Endocrine disease -- Overall association: supported by some evidence -- Immune system disease -- Overall association: supported by some evidence -- Environment disease -- Trauma -- Overall association: supported by strong evidence -- Body stuf ng and packing -- Overall association: supported by strong evidence -- Other pathological conditions -- Placental pathology -- Overall association: supported by some evidence -- Brain pathology -- Overall association: supported by some evidence -- Research concerns -- Chapter 4 Results: marijuana -- Introduction -- Background -- Infections -- Bacterial infections -- Comments -- Mycoses -- Comments -- Viral infections -- Comments -- Neoplastic disease -- Comments -- Musculoskeletal system disease -- Movement disorders -- Spinal cord function -- Comments -- Digestive system disease -- Stomatognathic disease -- Comments -- Respiratory system disease -- Comments -- Otorhinolaryngological disease -- Nervous system disease -- Neurodevelopment and neuropsychological studies -- Neurodevelopment -- Neuropsychological studies -- Comments.

Central nervous system disease -- Comments -- Chronobiology and sleep disorders -- Comments -- Neurological manifestations -- Comments -- Ocular disease -- Comments -- Male urological disease -- Renal disease -- Neoplastic disorders -- Male genitalia -- Comments -- Female genital and neonatal/congenital disorders -- Genital and pregnancy disorders -- Female genital disorders -- Pregnancy complications -- Comments -- Congenital, hereditary, and neonatal diseases and abnormalities -- Congenital disorders -- Congenital abnormalities -- Neonatal diseases -- Comments -- Cardiovascular disease -- Comments -- Dermatological disease -- Nutritional and metabolic disease -- Comments -- Endocrine system disease -- Comments -- Immune system disease -- Comments -- Environmental disease -- Trauma -- Injury risk and marijuana -- Substance abuse in trauma victims -- Problem drinkers and marijuana -- Other studies -- Comments -- Other pathological conditions -- Infections -- Bacterial infections -- Overall association: supported by some evidence -- Mycoses -- Overall association: not supported by evidence -- Viral (non-HIV) infections: liver damage and hepatitis C virus -- Overall association: supported by strong evidence -- Neoplastic disease -- Respiratory cancer -- Overall association: supported by some evidence -- Urinary bladder cancer -- Overall association: supported by some evidence -- Musculoskeletal system disease -- Propriospinal myoclonus -- Overall association: not supported by evidence -- Spasticity -- Overall association: supported by some evidence -- Stomatognathic disease -- Overall association: supported by some evidence -- Respiratory system disease -- Change in pulmonary function tests -- Overall association: supported by some evidence -- Pulmonary in ammation, chronic respiratory signs and symptoms.

Overall association: supported by some evidence.