
Calcium Binding Proteins.
Başlık:
Calcium Binding Proteins.
Yazar:
Permyakov, Eugene.
ISBN:
9780470872383
Yazar Ek Girişi:
Basım Bilgisi:
1st ed.
Fiziksel Tanımlama:
1 online resource (600 pages)
Seri:
Wiley Series in Protein and Peptide Science ; v.15
Wiley Series in Protein and Peptide Science
İçerik:
CALCIUM BINDING PROTEINS -- CONTENTS -- Preface -- 1 Historical Perspective -- 1.1 Biomineralization -- 1.2 Coagulation -- 1.3 Secondary Messengers (Anticipated) -- 1.4 Colloids -- 1.5 Cross-Linking and Cell Surfaces -- 1.6 Secondary Messengers (Updated) -- 1.7 Pumps, Channels, and Ionophores -- 1.8 Calcium Binding Proteins -- 1.9 Secondary Messengers (Yet Again) -- 1.10 Mitochondria -- 1.11 Pumps, Channels, and Ionophores -- 1.12 Hormones -- 1.13 Measurement -- 1.14 Biomineralization: Redux -- 2 Physiological Processes Involving Calcium Binding Proteins -- 2.1 Calcium as a Secondary Messenger -- 2.2 Calcium Buffers -- 2.3 Calcium Pumps and Channels -- 2.4 Mitochondria -- 2.5 Eubacteria -- 2.6 Calcium and Extracellular Proteins -- 2.7 Biomineralization -- 2.8 Calcium and Viruses -- 3 Comparison of the Ca2+ Ion with Other Metal Cations -- 3.1 Calcium Isotopes -- 3.2 Calcium in the Environment -- 3.3 Uses of Calcium -- 3.4 Health Effects of Calcium -- 3.5 Biologically Significant Metals in the Periodic Table -- 3.6 Hydration of Metal Ions -- 3.7 "Hard" and "Soft" Metal Ions -- 4 Complexes of Calcium and Other Cations with Compounds of Low Molecular Weight -- 4.1 Crystal Structures of Complexes of Calcium with Low Molecular Weight Compounds -- 4.2 Dissociation Constants of Calcium and Analogs with Small Compounds -- 4.3 Solubilities of Calcium and Analogs with Small Compounds -- 5 Stoichiometry, Kinetics, and Thermodynamics of Calcium Binding -- 5.1 Stoichiometry, Affinity, and Cooperativity of Binding -- 5.2 Kinetics of Binding -- 5.3 Partition of Free Energy of Binding (G) Among Enthalpy (H) and Entropy (S) -- 6 Experimental Methods Used to Study Calcium Binding to Proteins -- 6.1 Radioactivity -- 6.2 Ion-Selective Electrodes -- 6.3 Calcium Buffers -- 6.4 Dialysis, Equilibrium, and Flow -- 6.5 Proteolysis -- 6.6 Deuterium Exchange.
6.7 Isothermal Titration Calorimetry -- 6.8 Differential Scanning Calorimetry -- 6.9 Mass Spectroscopy -- 6.10 Calcium-Specific Dyes and Fluors -- 6.11 Atomic Flame Absorption Spectroscopy -- 6.12 Absorption Spectroscopy -- 6.13 Fluorescence Spectroscopy -- 6.14 Circular Dichroic and Optical Rotatory Dispersion Spectroscopy -- 6.15 Nuclear Magnetic Resonance -- 6.16 Electron Spin Resonance -- 6.17 Surface Plasmon Resonance -- 6.18 Extended X-ray Absorption Spectroscopy -- 6.19 Small Angle X-ray Scattering -- 6.20 Crystallography -- 7 Structure and Evolution of Proteins -- 7.1 Domain -- 7.2 Structure -- 7.3 Evolution -- 8 Protein Complexes with Metals Other than Calcium -- 8.1 Essential Hard Cations -- 8.2 Essential Metals with Several Valence States -- 8.3 Conclusions -- 9 Nonessential Metals -- 9.1 Alkali Metals (Group Ia) -- 9.2 Alkali Earth Metals (Group IIa) -- 9.3 Group IIIa -- 9.4 Group IVa -- 9.5 Group Va -- 9.6 Group VIIa -- 9.7 Group VIII -- 9.8 Group Ib -- 9.9 Mercury (Group IIb) -- 9.10 Group IIIb -- 9.11 Group IVb -- 9.12 Group Vb -- 9.13 Polonium (Group VIb) -- 9.14 Conclusions and Generalizations -- 10 Parvalbumin -- 10.1 Structure -- 10.2 Function -- 11 EF-Hand Proteins -- 11.1 CTER (Calmodulin, Troponin C, Essential and Regulatory Light Chain) Subfamily -- 11.2 CPR (Calcineurin B, p22, Recoverin) Subfamily -- 11.3 S100 Subfamily -- 11.4 Penta-EF-Hand Subfamily -- 11.5 Proteins with Six EF-Hands -- 11.6 Proteins with Eight and 12 EF-Hands -- 11.7 Proteins with Four EF-Hands -- 11.8 Proteins with Two EF-Hands -- 11.9 EF-Hand Proteins in Bacteria and Viruses -- 12 Cytosolic Calcium Binding Proteins Lacking EF-Hands -- 12.1 Annexins -- 12.2 C2-Domain Proteins -- 12.3 Calcium ATPases -- 12.4 Calcium Binding Proteins of the Endoplasmic Reticulum -- 13 Extracellular Calcium Binding Proteins -- 13.1 α-Lactalbumin -- 13.2 Cell Matrix Proteins.
13.3 Blood-Clotting Proteins -- 13.4 Osteocalcin -- 13.5 Calcium Binding Lectins -- 13.6 Calcium Binding Hydrolytic Enzymes -- 13.7 Miscellaneous -- 14 Interactions of Calcium Binding Proteins with Other Metal Ions -- 14.1 Magnesium -- 14.2 Sodium and Potassium -- 14.3 Zinc -- 14.4 Trace Metals -- 15 Interactions of Calcium Binding Proteins with Other Proteins and with Membranes -- 15.1 Interactions with Other Proteins -- 15.2 Interactions with Membranes -- 16 Genetic Engineering of Calcium Binding Proteins -- 16.1 Problems -- 16.2 Insertion of Reporter Groups -- 16.3 Mutations in Calcium Binding Sites -- 16.4 Mutations Elsewhere Than in Calcium Binding Sites -- 16.5 Generation of Chimeric Proteins -- 16.6 Creation of Calcium Binding Sites in Proteins -- 16.7 Studies of Protein-Protein and Protein-Membrane Interactions -- References -- Index.
Özet:
An up-to-date exploration on the latest developments in all the major families of calcium binding proteins Playing a prominent role as a signal transducer, calcium is an important participant in the communication pipeline directing cellular activity. This expert guide explains the unique and highly diverse functions of calcium in biology, culminating with a discussion of the calcium binding proteins that act as secondary messengers in cells and are responsible in controlling vital bodily mechanisms such as muscle contraction and the regulation of enzymes. A comprehensive volume reflecting breakthrough science, Calcium Binding Proteins: Contains current information on all major families of calcium binding proteins including their structural, physico-chemical and functional properties, as well as their evolution Discusses techniques that underlie the description of proteins, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry, and crystallography Describes the structures, physical characteristics, functions, and general patterns in the evolution of calcium binding proteins This book relies on the most current biological findings to cover the patterns of biochemical phenomena such as calcium homeostasis, min-eralization, and cell signaling involving specific proteins. Summarizing ongoing studies and presenting general hypotheses that help to focus future research, Calcium Binding Proteins provides newcomers to this field as well as established professionals with a conceptual framework instru-mental in advancing their scientific pursuits.
Notlar:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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