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Design and synthesis of rhodamine based fluorescent and colorimetric sensors for the detection of gold ions için kapak resmi
Design and synthesis of rhodamine based fluorescent and colorimetric sensors for the detection of gold ions
Karakuş, Erman, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
xiv, 112 leaves: illustrarions, charts;+ 1 computer laser optical disc.
The usage of chemosensors for the detection of heavy and transition metal ions is prevalent. Because these metal ions play crucial roles in living systems and have extremely toxic effects on the environment. Among these metal ions, gold species have interesting biological properties and uses. They play important roles in biological systems and often have significant impacts on human health. For instance, gold based drugs have long been used in the treatment of rheumatoid arthritis and other autoimmune diseases. In addition, gold nanoparticles function as carriers for drugs and gene delivery systems. Gold ions, on the other hand, are potentially toxic to humans. Because of their reactive nature, ionic gold species can interact with proteins, DNA and other biomolecules and disturb a series of cellular processes, leading to serious health problems. Detection of gold ions can be performed by spectroscopic methods such as atomic absorption and atomic emission spectroscopy and inductively-coupled plasma spectrometry that required complicated sample preparation steps, and sophisticated instrumentation. In contrast to these highly expensive and time consuming methods, fluorogenic or chromogenic methods can be good alternatives for the detection of these species that provides high analyte sensitivity and selectivity, visual simplicity, instantaneous response, as well as real time monitoring. The rhodamine scaffold is an ideal template for the construction of metal ion chemosensors because they have large molar extinction coefficient, long excitation and emission wavelengths, high fluorescence quantum yields, good water solubility, and the potential for colorimetric and turn-on fluorescent detection. In this thesis work, we focus on design and synthesis of novel rhodamine based molecules for the detection of gold ions. Moreover, we investigate the photophysical properties of synthesized molecules in the absence and presence of gold ions in both synthetic samples and living cells.
Yazar Ek Girişi:
Tek Biçim Eser Adı:
Thesis (Doctoral)--İzmir Institute of Technology:Chemistry.

İzmir Institute of Technology:Chemistry--Thesis (Doctoral).
Elektronik Erişim:
Access to Electronic Versiyon.


Materyal Türü
Demirbaş Numarası
Yer Numarası
Durumu/İade Tarihi
Tez T001652 TP159.C46 K18 2017

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