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Development of conductive oxide based thin film modified electrodes and biosensors applications için kapak resmi
Development of conductive oxide based thin film modified electrodes and biosensors applications
Yurttaş, Betül, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
x, 66 leaves: charts+ 1 computer laser optical disc.
From the first biosensor produced in 1956 to the present day, biosensors have been highly developed and diversified. In biosensor manufacturing, thin films have become a rapidly emerging field. Depending on the thin film material used, thin films have many advantageous properties for biosensors, such as high surface-to-volume ratio, conductivity, stability, specificity, biocompatibility, and good electrocatalytic activity. Dopamine is a neurotransmitter that has a significant impact on the emergence and treatment of certain diseases such as Alzheimer's and Parkinson's diseases. Dopamine monitoring is important for the prevention of these diseases, and it is a favorable option to use biosensors, which are useful and practical tools, instead of time-consuming and expensive conventional methods. For this purpose, in this thesis, a non-enzymatic electrochemical biosensor based on thin film electrodes was developed for monitoring dopamine levels. The electrodes were developed by deposition of Zn2SnO4 (ZTO) thin film on ITO thin film substrate by DC magnetron sputtering technique. The properties of the electrodes were determined by thickness, optical transmittance, XRD and SEM analysis. Electrochemical analysis, namely CV, EIS and DPV measurements, were performed before and after the electrodes were sonicated and modified with APTES before their application to the voltammetric detection of dopamine. In addition, electrochemical measurements were performed before/after sonication, APTES modification. Dopamine was detected by a voltammetric method using DPV technique. Furthermore, experiments in the presence of interferents such as ascorbic acid (AA), uric acid (UA) etc. showed that the thin film electrodes can be successfully applied for voltammetric determination of dopamine. As a result, the biosensor technology developed in this study has the potential to be wearable in the future, enabling non-invasive monitoring of dopamine levels in body fluids such as saliva, tears and sweat.
Tek Biçim Eser Adı:
Thesis (Master)--İzmir Institute of Technology: Bioengineering.

İzmir Institute of Technology: Bioengineering--Thesis (Master).
Elektronik Erişim:
Access to Electronic Versiyon.


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Durumu/İade Tarihi
Tez T002385 QD571 .Y95 2021

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