Metabolic acidosis -- Contents -- The hydrogen ion in normal metabolism -- Discussion -- The techniques and uses of intracellular pH measurements -- Discussion -- Energy metabolism and cellular pH in normal and pathological conditions. A new look through 31phosphorus nuclear magnetic resonance -- Discussion -- Acidosis and contractility of heart muscle -- Discussion -- Lactic acidosis in the brain: occurrence, triggering mechanisms and pathophysiological importance -- Discussion -- Glutamine metabolism in metabolic acidosis -- Discussion -- The regulation of ketogenesis -- Discussion -- General discussion I -- Fasting and ketone body metabolism -- Metabolic acidosis in exercise: (i) The fate of carboxylate ions during exercise -- (ii) Clinical measurements of lactate loads -- Preliminary observations on the metabolic responses to exercise in humans, using 31phosphorus nuclear magnetic resonance -- Discussion -- Metabolic acidosis and changes in water and electrolyte balance after maximal exercise -- Some hormonal influences on glucose and ketone body metabolism in normal human subjects -- Discussion -- Effects of free fatty acids, insulin, glucagon and adrenaline on ketone body production in humans -- Discussion -- Quantitative aspects of L(+)-lactate metabolism in human beings -- Discussion -- The role of catecholamines in metabolic acidosis -- Discussion -- Acid-base balance in diabetic ketoacidosis -- Discussion -- Isotope turnover studies in uncontrolled diabetes and the effects of insulin -- Discussion -- Metabolic acidosis in the critically ill -- Discussion -- The role of altered lactate kinetics in the pathogenesis of Type B lactic acidosis -- Discussion -- Organic acidurias: approach, results and clinical relevance -- Discussion -- Problems in the congenital lactic acidoses -- Discussion -- GENERAL DISCUSSION II.

Regulation of energy metabolism, gluconeogenesis and ketogenesis -- The role of lactate in exercise -- The relationship between intracellular and extracellular pH -- Hormonal regulation of ketogenesis -- Treatment of metabolic acidosis -- Chairman's summary -- Appendix -- Index of contributors -- Subject index.