FrontMatter -- Preface -- Contents -- Introduction -- Building the Case for Science-based Guidelines-Introductory Remarks--Hilton J. Klein -- Plenary Lecture -- Genes, Environments, and Mouse Behavior--John C. Crabbe -- Session 1 Current Status: Identifying the Issues -- AAALAC International Perspective--John G. Miller -- The Council of Europe: What Is It?--Wim deLeeuw -- ICLAS and the International Community--Gilles Demers -- Role of the National Institutes of Health Office of Laboratory Animal Welfare and the Public Health Service Policy on Humane Care and Use of Laboratory Animals--Nelson L. Garnett -- Regulatory Authority of the US Department of Agriculture Animal and Plant Health Inspection Service--Chester A. Gipson -- A Review and Comparison of Processes to Change Regulatory Guidelines: A European Perspective--Jonathan Richmond -- Japanese Regulations on Animal Experiments: Current Status and Perspectives--Naoko Kagiyama and Tatsuji Nomura -- Process for Change-Development and Implementation of Standards for Animal Care and Use in Canada--Clément Gauthier -- Building Credible Science from Quality, Animal-based Information--Paul Gilman -- Session 2 Assessment of Animal Housing Needs in the Research Setting- Peer-reviewed Literature Approach -- Disruption of Laboratory Experiments Due to Leaching of Bisphenol A from Polycarbonate Cages and Bottles and Uncontrolled Variability in Components of Animal Feed--Frederick S. vom Saal, Catherine A. Richter, Rachel R. Ruhlen, Susan C. Nagel, and Wade V. We -- Assessment of Animal Housing Needs in the Research Setting Using a Peer-reviewed Literature Approach: Dogs and Cats--Graham Moore -- Housing for Captive Nonhuman Primates: The Balancing Act--Melinda Novak -- Assessment of Animal Housing Standards for Rabbits in a Research Setting--Markus Stauffacher and Vera Baumans.

Session 3 Approaches to Current Guidelines- United States and Europe -- Housing Standards: Development of Guidelines and the Process for Change--William J. White -- Revision of Appendix A to the European Convention ETS 123: The Participants, the Process, and the Outcome--Derek Forbes -- Breakout Session: Rats and Mice -- Effects of Housing Density and Cage Type on Young Adult C57BL/6J Mice -- New Housing Standards for Rats and Mice Developed with Focus on the Needs of the Animals -- Breakout Session: Approaches for Implementing Current US and European Guidelines for Housing Standards for Dogs and Cats -- Breakout Session: Nonhuman Primates -- Breakout Session: Rabbit Housing -- Session 4 Environmental Control for Animal Housing -- Environmental Controls (US Guidance)--Bernard Blazewicz and Dan Frasier -- European Guidelines for Environmental Control in Laboratory Animal Facilities--Harry J. M. Blom -- Breakout Session: Lighting -- Breakout Session: Effects of Sound on Research Animals -- Breakout Session: Environmental Control for Animal Housing- Impact on Metabolism and Immunology -- Breakout Session: Environmental Control/ Engineering Issues -- Dinner Speaker--Kay E. Holekamp -- A View from the Field: What the Lives of Wild Animals Can Teach Us About Care of Laboratory Animals--Kay E. Holekamp -- Session 5 Environmental Enrichment Issues -- Enriching the Housing of the Laboratory Rodent: How Might It Affect Research Outcomes?--William T. Greenough and Ann Benefiel -- Search for Optimal Enrichment--Timo Nevalainen -- Breakout Session: Environmental Enrichment Issues: Mice/Rats/Rabbits -- Breakout Session: Environmental Enrichment for Dogs and Cats -- Breakout Session: Assessment of Nonhuman Primate Enrichment- Science Versus Welfare Concerns -- Point/Counterpoint: The Cases For and Against Harmonization.

Point/Counterpoint: The Cases For and Against Harmonization--William S. Stokes -- Appendixes -- Appendix A: International Workshop on Development of Science-based Guidelines for Laboratory Animal Care -- Appendix B: Workshop Faculty -- Appendix C: Committee Bios -- Appendix D: International Guiding Principles for Biomedical Research Involving Animals (1985).