Libraries accumulate and protect written and printed works that make permanent knowledge and cultures have been accumulated throughout human history. Paper-based collections kept in libraries are the heritage of humanity. They are under risk of mechanical, biological and chemical degradation over the years caused by the fluctuations in temperature and relative humidity values and inability to control these values. The aim of the Thesis is to reduce degradation risks on paper-based collections in historic libraries by providing preventive conservation without damaging the structure of the building. The historic Necip Paşa Library which is home for 1147 manuscripts was chosen as a case study. In order to provide preventive conservation for manuscripts, firstly indoor microclimatic data were collected for one year and analyzed to observe the risks that may cause degradation types on manuscripts. Only chemical degradation risk was detected. Window controlled seven natural ventilation scenarios were developed to reduce the risk. Finally, ventilation scenarios were analyzed by Ansys Fluent 17.1. Computational Fluid Dynamics (CFD) modelling was used to observe the effect of natural ventilation scenarios on indoor relative humidity according to outdoor relative humidity and wind direction. Finally, k-ε turbulence model was used in CFD analysis. Results shows that during the high chemical degradation risk period (May-October), outdoor air temperature and relative humidity are suitable only 7.53% of the total time which allows appropriate natural ventilation. As a conclusion, natural ventilation is not enough to decrease chemical degradation risk totally for the Library. Therefore, additional mechanical ventilation is required.