Interactions between metal surfaces and sulfur-containing amino acids için kapak resmi
Interactions between metal surfaces and sulfur-containing amino acids
Başlık:
Interactions between metal surfaces and sulfur-containing amino acids
Yazar:
Çevlikli, Mustafa, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
vii, 39 leaves: charts;+ 1 computer laser optical disc.
Özet:
With Covid-19 pandemic, the scientific studies over viruses gained a big acceleration. Some of these studies show that SARS-CoV-2 can infect through direct ways from a patient. Besides that, surfaces that are contaminated from adsorption of the virus can indirectly infect a person. Because of this, the studies on the interaction between viruses and environment is an important field on virus studies. Spike proteins which project out from protective structure called lipid bilayer and they are outmost elements of SARS-CoV-2 viruses. Spike proteins play a vital role on functions like viral entry to the host cell and attachment to the surfaces. Purpose of this study is to contribute to the existing knowledge about surface interaction of these proteins which have an important role on virus-surface interactions. Because of the complicated physical and chemical form of proteins, in this study, the interaction of amino acids, which are building block of proteins, with metal surfaces are investigated. 0.01M, 0.02M and 0.05M L-cysteine and L-methionine aqueous solution was dropped to the metals frequently used in daily life, chrome (Cr) and iron (Fe) polycrystalline substrates and left to dry out at room temperature and under atmospheric conditions. Since the water solubility of L-cystine is low, only a saturated solution of Lcystine was prepared and same process was applied. After, dried out samples were analyzed with x-ray photoelectron spectroscopy (XPS). Functional sulfur groups on L-cysteine/Cr, L-methionine/Cr and L-Methionine/Fe system stayed intact. On the other hand, sulfur atoms on L-Cysteine/Fe system oxidized and formed 􀵆􀜵􀜱􀯫 species. While all other systems behaved oppositely, the amount of protonated functional amino species (􀵆􀜰􀜪􀬷 􀬾) on L-methionine/Fe system decreased relative to functional amino group (􀵆􀜰􀜪􀬶) with increase in coverage. Due to surface amino acid interaction of L-methionine in different substrates, binding energy of sulfur on iron was measured 1 eV lower than on chromium. In L-cystine/Cr system, while disulfide bonds stayed intact, 􀵆􀜰􀜪􀬶 and 􀵆􀜰􀜪􀬷 􀬾 functional groups were observed on the surface together.
Yazar Ek Girişi:
Tek Biçim Eser Adı:
Thesis (Master)--İzmir Institute of Technology:Physics

İzmir Institute of Technology:Physics. --Thesis (Master).
Elektronik Erişim:
Access to Electronic Versiyon.
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