When Hellboy, Liz Sherman, and Abe Sapien are assigned to investigate the ghost-infested mansion of a publicity hound billionaire, they uncover a plot to resurrect a beautiful yet monstrous vampire from Professor Bruttenholm's past. But before they can stop her bloodbath, Hellboy will have to battle harpies, hellhounds, a giant werewolf and even the ferocious goddess Hecate herself.