Enzyme Defects and Immune Dysfunction -- Contents -- Chairman's introduction -- Adenosine deaminase and purine nucleoside phosphorylase deficiency: how they were discovered and what they may mean -- Discussion -- Buridan's ass: one man's view of the immune system -- Discussion -- Clinical delineation of adenosine deaminase deficiency -- Discussion -- Immunological aberrations in purine nucleoside phosphorylase deficiencies -- Discussion -- Immunodeficiency due to transcobalamin II deficiency -- Discussion -- General Discussion I Model systems for study of enzyme deficiencies -- Nucleotide metabolism in cultured T cells and in cells of patients deficient in adenosine deaminase and purine nucleoside phosphorylase -- Discussion -- Deoxyribonucleoside toxicity in adenosine deaminase and purine nucleoside phosphorylase deficiency: implications for the development of new immunosuppressive agents -- Discussion -- Ecto 5'-nucleotidase deficiency in primary hypogammaglobulinaemia -- Discussion -- General Discussion II The methylation hypothesis of adenosine toxicity -- Enzymology of immunodeficiency states -- Allosteric regulation of calf thymus ribonucleotide reductase -- Discussion -- Adenosine deaminase: characteristics of the normal and mutant forms of the human enzyme -- Discussion -- Purine nucleoside phosphorylase: the normal enzyme and structural alterations in immunodeficiency disease -- Discussion -- Purine nucleoside phosphorylase : immunodetection and characterization of the human enzyme -- Enzyme replacement and other biochemical approaches to the therapy of adenosine deaminase deficiency -- Discussion -- An approach to the restoration of T cell function in a purine nucleoside phosphorylase deficient patient -- Discussion -- Purine metabolism in adenosine deaminase deficiency.

Final General Discussion Selective treatment of lymphoid malignancy with adenosine deaminase inhibitors -- Defects in differentiation underlying ADA and PNP deficiency -- Search for new enzyme deficiencies -- Index of contributors -- Subject index.