Xylan based composite nanoparticles and biofoams for drug delivery and tissue engineering için kapak resmi
Xylan based composite nanoparticles and biofoams for drug delivery and tissue engineering
Başlık:
Xylan based composite nanoparticles and biofoams for drug delivery and tissue engineering
Yazar:
Zeybek, Nüket, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
xi, 151 leaves: charts;+ 1 computer laser optical disc.
Özet:
Xylan is a hemicellulosic polysaccharide, which can be obtained from forest and agricultural wastes. Similar to some other polysaccharides, xylan can find application in drug delivery and tissue engineering due to its availability, structural diversity, biocompatibility, biodegradability, and low cost. In the first part of the study, xylan-based nanoparticles were developed for colontargeted oral drug delivery. Xylan is resistant to digestion and absorption in the upper GIT and is degraded by hydrolysis of glycosidic bonds by the colon microbiota; this makes it prominent in targeted drug delivery to the colon. The drug carrier was combined with a polymeric micelles system to increase the bioavailability of hydrophobic bioactive molecules in the colon targeting. The model hydrophobic molecule, curcumin, was loaded in the core of the triblock copolymer P-123 micelles by the thin-film hydration method. Curcumin-loaded micelles were coated with xylan supported by chitosan and tripolyphosphate using the ionic gelation method. In another approach, xylan was also used to coat curcumin-loaded mesoporous silica nanoparticles to prevent premature drug release in the upper GIT in colon-targeted delivery. In both approaches, the drugcontaining structures were maintained up to the colon and the drug was released upon bacterial hydrolysis of xylan. In the second part, xylan-based biofoams were synthesized by the oil in water emulsion templated method. Several physicochemical and mechanical tests have shown that at the optimal conditions foams with promising properties could be synthesized. Besides, to develop a more effective tissue therapy by utilizing the synergistic effect of the drug delivery and scaffold system, a model drug was successfully loaded into biofoams. This study showed that xylan is a promising feedstock for the synthesis of stable and biocompatible materials in biomedical applications, which reveals its potential capability in drug carriers and scaffolds.
Tek Biçim Eser Adı:
Thesis (Doctoral)--İzmir Institute of Technology:Bioengineering

İzmir Institute of Technology:Bioengineering--Thesis (Doctoral).
Elektronik Erişim:
Access to Electronic Versiyon.
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