Synthesis, characterization and investigation of cytotoxic effects of drug loaded zif-8 metal-organic frameworks
Başlık:
Synthesis, characterization and investigation of cytotoxic effects of drug loaded zif-8 metal-organic frameworks
Yazar:
Mete, Derya, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
xii, 124 leaves: charts;+ 1 computer laser optical disc.
Özet:
The biocompatible ZIF-8 intelligent material, a member of the metal-organic framework family, has a biodegradable property in an acidic environment due to its poor coordination bonds. Because cancerous cells are more acidic than healthy cells, our studies aim to ensure that doxorubicin, sorafenib, and apalutamide, encapsulated in ZIF8, target cancer cells responsive to pH, thereby reducing damage to healthy cells. In addition, ZIF-8 was selected not only as a carrier system but also as a therapeutic effect. Because ZIF-8 material is biodegradable, it is divided into zinc and 2-methylimidazole components in cancer cells. Research shows that the decrease in the amount of zinc is essential in the formation of cancer cells. Zinc is reported to be in lower intracellular concentrations in HCC and prostate cell lines instead of healthy variants. It aims to create dual cytotoxic effects on cancer cells by combining the effects of zinc-drug on a single platform.
Konu Başlığı:
Yazar Ek Girişi:
Tüzel Kişi Ek Girişi:
Tek Biçim Eser Adı:
Thesis (Doctoral)--İzmir Institute of Technology: Chemistry
İzmir Institute of Technology: Chemistry--Thesis (Doctoral).
Elektronik Erişim:
Access to Electronic Versiyon.