The built environment is at risk of facing significant impacts due to climate change and extreme weather occurrences. An adverse consequence of climate change on the construction industry is the degradation of thermal comfort within buildings, leading to increased energy usage for air conditioning. Because existing residential buildings are unprepared for the future climate. The Mediterranean climate is one of the climate classes that will be mostly affected by the global climate, especially in terms of temperature increases. Yet, to access sensitive and accurate climatic data and find the best retrofit scenarios is problematic. Two IoT devices were used in this study to overcome this problem. This study aims to observe and minimize the energy consumption and thermal heat comfort of the flat on the ground floor of a 3-story residential building located in Aydın province, which has a Mediterranean climate, against climatic conditions. In the study, climate predictions for 2049-2050 and 2079- 2080 were also made, and it was investigated whether the currently optimized building would remain optimized in future climate conditions. According to the results, while the cooling energy consumption of the currently optimized building decreased by 43% compared to the base case, it decreased by 25% according to the 2049-2050 climate predictions and by 8% according to the 2079-2080 climate predictions. There was no visible change in discomfort hours. In the separate optimization results for the 2049- 2050 and 2079-2080 periods of the building, which could not remain optimized according to future climate conditions, a 30% and 21% decrease in cooling energy consumption was observed, respectively, compared to the base case. There was no visible change for discomfort hours. According to this study, it was concluded that the building should be re-optimized in future climate scenarios