Synthesis of 1,2,3-triazole substituted azacoumarin derivatives as potential antiproliferative compounds için kapak resmi
Synthesis of 1,2,3-triazole substituted azacoumarin derivatives as potential antiproliferative compounds
Başlık:
Synthesis of 1,2,3-triazole substituted azacoumarin derivatives as potential antiproliferative compounds
Yazar:
Erdoğmuş, Mustafa, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
xiv, 77 leaves: charts;+ 1 computer laser optical disc.
Özet:
Cancer is one of the deadly diseases that affects millions of people every year and causes death. Although studies toward its treatment are very promising, they are not sufficient. Therefore, the need for new and powerful molecules with less side effects is increasing day by day. 1-Azacoumarin derivatives are molecules whose potential biological activity has just begun to be understood, but not enough research has been done on them. 1,2,3-Triazole structures, on the other hand, are a very important family of molecules in some drugs, whose biological effects have been known for many years. It is known that they have important roles in cancer-preventing mechanisms in various types of cancer. In this study, two different 1,2,3-triazole 1-azacoumarin derivatives were tried to be synthesized. For structure 149, it was aimed to form yinon first and then formation of 1,2,3-triazole was studied but failed. Afterwards, the emphasis was placed on the production of 1-azacoumarin, and then click chemistry experiments were carried out in the presence of copper (I) catalyst. Finally, click chemistry studies were tested in the presence of a nickel catalyst for structure 150. Triazole formation experiments were carried out by click chemistry in the presence of copper catalyst after 1-azacoumarin was obtained.
Konu Başlığı:
Yazar Ek Girişi:
Tek Biçim Eser Adı:
Thesis (Master)--İzmir Institute of Technology: Chemistry.

İzmir Institute of Technology: Chemistry--Thesis (Master).
Elektronik Erişim:
Access to Electronic Versiyon.
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