Contents -- Chapter 1 Introduction and Structure of the Book -- Why Organic Synthesis Engineering -- The Organic Chemicals Ladder and the Role of Catalysis -- Process Intensification -- Structure of the Book -- Internal Organization of Chapters -- PART I: REACTIONS AND REACTORS IN ORGANIC SYNTHESIS: BASIC CONCEPTS -- Chapter 2 Rates and Equilibria in Organic Reactions: The Thermodynamic and Extrathermodynamic Approaches -- Basic Thermodynamic Relationships and Properties -- Thermodynamics of Reactions in Solution -- The Extrathermodynamic Approach -- Extrathermodynamic Relationships between Rate and Equilibrium Parameters -- Chapter 3 Estimation of Properties of Organic Compounds -- Correlation Strategy -- Basic Properties -- Thermodynamic and Equilibrium Properties -- Reaction Properties -- Transport Properties -- Surface Tension and Ultrasonic Velocity -- Chapter 4 Reactions and Reactors: Basic Concepts -- Reaction Rates -- Stoichiometry of the Rate Equation -- Reactors -- Transport between Phases -- Laboratory Reactors -- Chapter 5 Complex Reactions -- Reduction of Complex Reactions -- Rate Equations -- Selectivity and Yield -- Simultaneous Homogeneous and Catalytic (or Autocatalytic) Reactions -- Notation to Part I -- References to Part I -- PART II: CATALYSIS IN ORGANIC SYNTHESIS AND TECHNOLOGY -- Chapter 6 Catalysis by Solids, 1: Organic Intermediates and Fine Chemicals -- Modified Forms of the More Common Catalysts -- Zeolites -- Heteropolyacid Catalysts -- Clays in Catalysis: A Class of Supported Reagents -- Solid Superacids -- Solid Base Catalysts -- Metallic Glass Catalysts -- Ion-Exchange Resins -- Catalysis by Inclusion: Cyclodextrins -- Titanates -- Catalysts for Selected Classes of Reactions -- "Heterogenized" Homogeneous Catalysts -- Role of Solvent in Catalysis by Solids.

Chapter 7 Catalysis by Solids, 2: The Catalyst and Its Microenvironment -- Modeling of Solid Catalyzed Reactions -- Role of Diffusion in Pellets: Catalyst Effectiveness -- Effect of External Mass and Heat Transfer -- Combined Effects of Internal and External Diffusion -- Relative Roles of Mass and Heat Transfer in Internal and External Diffusion -- Regimes of Control -- Eliminating or Accounting for Transport Disguises -- Experimental Reactors -- Chapter 8 Homogeneous Catalysis -- Homogeneous versus Heterogeneous Catalysis -- Formalisms in Transition-Metal Catalysis -- The Operational Scheme of Homogeneous Catalysis -- The Basic Reactions of Homogeneous Catalysis -- Main Features of Transition-Metal Catalysis in Organic Synthesis: A Summary -- Important Classes of Reactions with Industrial Examples -- General Kinetic Analysis -- Chapter 9 Asymmetric Synthesis -- Basic Definitions/Concepts -- Methods of Preparing Pure Enantiomers -- Asymmetric Synthesis -- Homogeneous Asymmetric Catalysis -- Heterogeneous Asymmetric Catalysis -- Notation to Part II -- References to Part II -- PART III: REACTOR DESIGN FOR HOMOGENEOUS AND FLUID-SOLID (CATALYTIC) REACTIONS -- Chapter 10 Reactor Design for Simple Reactions -- Plug-Flow Reactor with Recycle -- Mixed-Flow Reactors in Series -- Semibatch Reactors -- Varying Volume Reactors -- Measures of Mixing: Comparison of the Series, Recycle, and Variable Volume Reactors -- Comments -- Chapter 11 Reactor Design for Complex Reactions -- Batch Reactor -- Plug-Flow Reactor -- Continuous Stirred Tank Reactor -- Reactor Choice for Maximizing Yields and Selectivities -- Optimum Temperatures or Temperature Profiles for Maximizing Yields and Selectivities -- Chapter 12 Reactor Design for Solid-Catalyzed Fluid Phase Reactions -- Fixed-Bed Reactor -- Fluidized-Bed Reactor -- Reactor Choice for a Deactivating Catalyst.

Chapter 13 Mixing, Multiple Solutions, and Forced Unsteady-State Operation -- Role of Mixing -- Multiple Solutions -- Notation to Part III -- References to Part III -- PART IV: FLUID-FLUID AND FLUID-FLUID-SOLID REACTIONS AND REACTORS -- Chapter 14 Gas-Liquid Reactions -- The Basis -- Diffusion Accompanied by an Irreversible Reaction of General Order -- Effect of Temperature -- Discerning the Controlling Regime in Simple Reactions -- Diffusion Accompanied by a Complex Reaction -- Simultaneous Absorption and Reaction of Two Gases -- Absorption of a Gas Followed by Reaction with Two Liquid-Phase Components -- Extension to Complex Rate Models: Homogeneous Catalysis -- Measurement of Mass Transfer Coefficients -- Examples of Gas-Liquid Reactions -- Chapter 15 Liquid-Liquid and Solid-Liquid Reactions -- Liquid-Liquid Reactions -- Solid-Liquid Reactions -- Chapter 16 Gas-Liquid and Liquid-Liquid Reactor Design -- A Generalized Form of Equation for All Regimes -- Classification of Gas-Liquid Contactors -- Reactor Design for Gas-Liquid Reactions -- Reactor Choice for Gas-Liquid Reactions -- Liquid-Liquid Contactors -- Stirred Tank Reactor: Some Practical Considerations -- Chapter 17 Multiphase Reactions and Reactors -- Analysis of Three-Phase Catalytic Reactions -- Design of Three-Phase Catalytic Reactors -- Types of Three-Phase Reactors -- Collection and Interpretation of Laboratory Data for Three-Phase Catalytic Reactions -- Examples of Three-Phase Catalytic Reactions in Organic Synthesis and Technology -- Three-Phase Noncatalytic Reactions -- Notation to Part IV -- References to Part IV -- PART V: STRATEGIES FOR ENHANCING THE RATES OF ORGANIC REACTIONS -- Chapter 18 Biphasic Reaction Engineering -- Equilibria in Biphasic Reactions -- Solvent Selection -- Role of Aqueous Phase Volume -- Matching the pH Optima for Reaction Equilibrium and Catalyst Activity.

Modeling of Biphasic Biocatalytic Systems -- Use of Biphasing in Organic Synthesis -- Examples of Biphasing -- Chapter 19 Phase-Transfer Reaction Engineering -- General Features -- Kinetics and Modeling of Soluble PTC -- Immobilized PTC -- Industrial Applications of PTC -- Chapter 20 Bioorganic Synthesis Engineering -- Microbes and Enzymes -- Kinetics and Modeling of Bioreactions -- Bioreactors -- Examples of the Use of Biocatalysts in Organic Synthesis -- Chapter 21 Electroorganic Synthesis Engineering -- Basic Concepts and Definitions -- Modeling of Electroorganic Reactions and Reactors -- Reaction Modeling -- Reactor Modeling -- Scale-Up of Electrochemical Reactors -- Industrial Electrochemical Cell Components and Configurations -- Selected Examples of Industrial Electroorganic Synthesis -- Chapter 22 Sonoorganic Synthesis Engineering -- Devices for Producing Ultrasound -- Homogeneous Reactions -- Heterogeneous Reactions -- Ultrasound in Organic Synthesis -- Scale-Up of Sonochemical Reactors -- Design of Cavitation Reactors -- Sonochemical Effect without Ultrasound: Hydrodynamic Cavitation -- Chapter 23 Microphase-Assisted Reaction Engineering -- Classification of Microphases -- Analysis of Microphase Action -- Microphase as a Chemical (Catalytic) or Physical Sink -- Microphase as a Physical Carrier -- Microphase as a Source-Reactant as Microphase -- Solid Product as a Microphase-Microphase-Assisted Autocatalysis -- Chapter 24 Membrane-Assisted Reactor Engineering -- General Considerations -- Modeling of Membrane Reactors -- Operational Features -- Comparison of Reactors -- Examples of the Use of Membrane Reactors in Organic Technology and Synthesis -- Chapter 25 Multifunctional Reactor Engineering -- Reaction-Extraction -- Distillation-Reaction -- Chapter 26 Other Important (and Some Lesser Known) Strategies of Rate Enhancement.

Photochemical Enhancement -- Enhancement by Micelles -- Microwave-Assisted Organic Synthesis -- Organic Synthesis in Supercritical Fluids -- Use of Hydrotropes (Hydrotropic Solubilization) -- Combinatorial Strategies -- Use of Micromixing and Forced Unsteady-State Operation -- Notation to Part V -- References to Part V -- A Process Overview -- Epilogue -- Acknowledgments for Figures and Tables -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Y -- Z.